Human skin organoid

Image Credit: Mustafa Shehadeh from Pixabay
A human skin organoid model of tissue resident immunology for screening and validating tissue resident immune modulating therapeutics.
About the Technology
A human skin organoid model of tissue resident immunology for screening and validating tissue resident immune modulating therapeutics
The discovery and development of therapeutic options that directly target the root pathology of skin diseases has been hindered by the limitations of current in vitro skin models which have failed to preserve or recapitulate the full cellular complexity of human skin.
To solve this issue, we successfully developed human skin organoids where intact fragments of skin are grown long term (>100 days) preserving a full range of native epidermal and dermal elements without artificial reconstitution. Importantly, we preserve endogenous tissue resident immune architecture that is required to study treatment options for immune mediated skin conditions such as atopic dermatitis, psoriasis, vitiligo, prurigo nodularis, and cutaneous immune related adverse events (IRAEs) to drugs.
Our oganoid technology represents the most accurate and robust model of human skin to date, which we will use to assay for immunomodulating phenotypes to target in the development of novel therapeutics. HIT Fund support will advise the business/commercial development strategy of our technology.